Name ZahiPeriod
Date
Karyotyping Activity
Directions: In this activity, you will use a computer model to look at chromosomes and prepare a
karyotype. You will diagnose patients for abnormalities and learn the correct notation for characterizing
karyotypes.
Site 1: //www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping.html
Use the website above to answer the following questions below.
1. What causes a dark band on the chromosome? Bases that have a lot of adenine and
Thymine.
2. What is a centromere? The area where two chromatids joined.
Patient Histories:Click on Patient Histories. You will be completing a karyotype for Patient A, B, and C.
Patient A (Click on the link to "Complete Patient A's Karyotype")
Match the chromosome to its homolog. After all the matches are complete, you will analyze your patient.
(NOTE: Scroll down to the bottom of the page to view your completed karyotype).
3. Summarize the health history for patient A. Full term fetus of 40-year-old female
4. How many total chromosomes are in your karyotype? (Hint: actually count them.) 47
5. The last set of chromosomes are called the sex chromosomes, if you have two large chromosomes,
your patient is XX (female), one large and one small indicates XY (male). What type of sex chromosomes
does this patient have? XX
6. Which chromosome set has an extra chromosome? Y
7. What notation would you use to characterize Patient A’s karyotype? 47 XXY
8. What diagnosis would you give this patient (what disease)? Explain. Down syndrome
Patient B - click on the link to go to Patient B and repeat the above process.
9. Describe the health history for patient B. 28-year-old infertile male
10. How many total chromosomes are in your karyotype? (Hint: actually count them.) 47
11. What sex chromosomes does your patient have? XXY
12. Which chromosome set has an extra chromosome? X
13. What notation would you use to characterize Patient B’s karyotype? XXXY
14. What is the diagnosis for this patient? Explain. Klinefelter syndrome
Patient C - click on the link to go to Patient C and repeat the above process.
15. Describe Patient C’s health history. Died shortly after birth
16. How many total chromosomes are in your karyotype? (Hint: actually count them.) 47
17. What sex chromosomes does your patient have? XXY
18. Which chromosome set has an extra chromosome? X