Can you take mucinex and nyquil cold and flu together

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Breaks up mucus that causes cough.

Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.

3.8/ 5 average rating with 902 reviewsforMucinex

Relieves cold and flu symptoms, and helps you sleep.

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu

Upsides

  • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in liquid and tablet forms.
  • Mucinex (Guaifenesin) is alcohol- and sugar-free.

  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.

Downsides

  • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.

  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.

Used for

  • Expectoration (clearing) of mucus

  • Common cold
  • Flu

Dosage forms

  • Extended release
  • Liquid

  • Pill
  • Liquid

Price

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Reviews

Side effects

The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.

The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.

Risks and risk factors

  • Liver damage

    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Serotonin syndrome

    • Using other medications that affect serotonin
  • Driving impairment

    • Taking with alcohol
    • Taking with other medicines that make you less alert
  • Antihistamine side effects

    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)

See more detailed risks and warnings

Mar 24, 2019

Laurence asked

Can you tell me what is the difference between Mucinex and NyQuil? Which one would be better for me?

At a glance

  • Mucinex contains a single active ingredient, guaifenesin, an expectorant. NyQuil contains three active ingredients, acetaminophen (analgesic), dextromethorphan (cough suppressant) and doxylamine (sedating antihistamine). NyQuil Severe, another product in the NyQuil family, contains phenylephrine as well.

Answer

Can you take mucinex and nyquil cold and flu together

Mucinex and NyQuil are over the counter products that are used to treat symptoms of the cold and flu.

However, they contain different active ingredients.

In the next sections, I discuss NyQuil and Mucinex in more detail.

NyQuil is a combination ingredient medication intended to help ease the symptoms of a cold or flu and to help you fall asleep.

The sedating ingredient in NyQuil is doxylamine, a sedating antihistamine similar to Benadryl (diphenhydramine).

Aside from doxylamine, the other ingredients in NyQuil are acetaminophen (an analgesic) and dextromethorphan (a cough suppressant).

The NyQuil Severe formula also contains phenylephrine, a nasal decongestant.

NyQuil is a fast-acting medication, and you should feel like effects within 15 to 30 minutes after taking a dose by mouth. Each dose lasts four to six hours.

Mucinex contains guaifenesin, an expectorant.

It helps to thin and loosen mucus secretions, making them easier to expectorate (cough or spit out).

It is commonly referred to as a 'chest decongestant', and can also help reduce post-nasal drip.

Mucinex is a brand name product, and there are a number of 'Mucinex brand' products that contain additional ingredients.

For example, Mucinex Fast-Max Severe Congestion & Cough contains:

  • Guaifenesin (expectorant)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal decongestant)

If you are simply looking for an expectorant, stick with the original Mucinex product.

NyQuil Vs. Mucinex

As discussed in the above sections, NyQuil and Mucinex are both brand name products that are used to treat symptoms of the cold or flu.

The active ingredient in Mucinex is guaifenesin while NyQuil is a combination ingredient product, containing acetaminophen, dextromethorphan, and doxylamine (NyQuil Severe also contains guaifenesin).

Which product you choose should be based on your symptoms.

If you are only experiencing chest congestion, Mucinex is likely the product for you.

If you have a broader range of symptoms, such as a fever, cough and nasal congestion, NyQuil would be preferred (as long as you only take it at bedtime since it will make you drowsy).

Can you take mucinex and nyquil cold and flu together
References
  • Elsevier ClinicalKey: NyQuil Monograph
  • Elsevier ClinicalKey: Mucinex Monograph
  • NyQuil Manufacturer Website
  • Mucinex Manufacturer Website

What happens if you take Mucinex and Nyquil together?

The symptoms they treat are different. You can take Mucinex and NyQuil together safely if you follow the recommended dosage for each drug. However, taking Mucinex at night with NyQuil might actually keep you from falling asleep. Mucinex will loosen your mucus, which can cause you to wake up to cough.

Can you take Mucinex and cold and flu medicine together?

No interactions were found between Mucinex and Tylenol Cold & Flu Severe.

Can I take Mucinex and DayQuil at the same time?

No interactions were found between Mucinex and Vicks DayQuil Severe Cold & Flu.