Physiological reduction in fasting plasma glucose concentration in the first trimester of normal pregnancy: the diabetes in early pregnancy studyJ L Mills et al. Metabolism. 1998 Sep. Show
AbstractPrevious studies indicate that fasting plasma glucose decreases during gestation, but the timing and extent are not consistent from study to study. We had an opportunity to examine this question in the normal pregnancy cohort of women studied in the Diabetes in Early Pregnancy Study. Subjects were monitored to identify pregnancy by human chorionic gonadotropin testing, enrolled within 21 days of conception, and screened to rule out gestational diabetes at the juncture of the second and third trimesters. All subjects were instructed to fast overnight for 10 to 12 hours. Three hundred sixty-one women were studied between 6 and 12 weeks of gestation. A median decrease in plasma glucose of 2 mg/dL was observed between weeks 6 and 10 (P=.007). In a smaller group of subjects evaluated through the third trimester, little further glucose reduction was observed. A reduction in glycosylated hemoglobin levels between 10 and 20 weeks (P=.002) followed the earlier reduction in first trimester glucose levels. Analysis by body mass index (BMI) showed a smaller first trimester reduction with increasing BMI, and none among severely obese women (BMI > 29.9 kg/m2). The decline in fasting plasma glucose in pregnancy begins early in the first trimester, well before fetal glucose requirements can contribute to the decline in the glucose level. Thereafter, plasma glucose levels decrease little. These results suggest that in the setting in which this study was performed (an overnight fast) maternal physiologic adjustments account for a reduction in plasma glucose early in the first trimester of pregnancy, and possibly even later in gestation as well. Similar articles
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Why my fasting sugar is high during pregnancy?During pregnancy, your placenta makes hormones that cause glucose to build up in your blood. Usually, your pancreas can send out enough insulin to handle it. But if your body can't make enough insulin or stops using insulin as it should, your blood sugar levels rise, and you get gestational diabetes.
How do I get my fasting numbers down for gestational diabetes?Medication and insulin
High fasting levels are very common with gestational diabetes and are the hardest level to control. For the majority struggling with high fasting levels, the only way to improve them is with the help of medication such as Metformin and/or insulin.
What can I eat at night to lower my fasting blood sugar gestational diabetes?Try one the following healthful snacks before bed to help manage blood sugar levels and satisfy nighttime hunger:. A handful of nuts. ... . A hard-boiled egg. ... . Low-fat cheese and whole-wheat crackers. ... . Baby carrots, cherry tomatoes, or cucumber slices. ... . Celery sticks with hummus. ... . Air-popped popcorn. ... . Roasted chickpeas.. How do I get my fasting blood sugar down?For some people, having some protein or healthy fat with about 15 grams of carbohydrate before bed helps keep the morning fasting numbers in target range. Try having a small amount of peanut butter on a piece of whole grain bread or 1 oz of low-fat cheese and a small apple.
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How to lower fasting glucose in pregnancy
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