Whooping cough vaccine while pregnant side effects

It is safe to have the whooping cough vaccine at the same time as the flu or coronavirus (COVID-19) vaccine, but it’s important that you don't delay any vaccination in order to have them at the same time.

The coronavirus vaccine is strongly recommended in pregnancy. Having all the recommended doses is important for longer-term protection against coronavirus. The coronavirus vaccine can be given at any stage during pregnancy and is the best way to protect you and your baby from the known risks of coronavirus in pregnancy.

If you're pregnant during the flu season (October to March), then you should have the flu vaccine as early as you can during pregnancy.

If you have any questions about vaccinations and when you will be offered them, please speak to your midwife.

In recent years, cases of whooping cough (also known as pertussis) have risen sharply across the UK. You can help protect your unborn baby from getting whooping cough in the weeks after birth by having the whooping cough vaccination while you are pregnant.

Covid-19 guidance for pregnant women and information on what is happening in their regional unit can be found on NI Maternity

Whooping cough

Whooping cough is a serious disease that causes long bouts of coughing and choking, making it hard to breathe. The ‘whoop’ noise is caused by gasping for breath after each bout of coughing.

Young babies are most at risk from whooping cough. For these babies, the disease is very serious and can lead to pneumonia and permanent brain damage. In the worst cases, it can cause death.

  • Whooping cough
  • Your local doctor (GP)

The vaccine

No single whooping cough vaccine is available. You will be given a vaccine already used as part of the childhood immunisation schedule that also protects against diphtheria, tetanus and polio.

The whooping cough vaccine isn’t live, so it can’t cause whooping cough in you or your baby. Having vaccines in pregnancy has been studied and no evidence of risk has been found. It’s much safer for you to have the vaccination than to risk your newborn baby catching whooping cough.

You may have some mild side effects from the vaccination such as swelling, redness or tenderness where the vaccine was given.  Serious side effects are extremely rare.

If you are pregnant during flu season, then you should have the flu vaccine as early as possible. If you are over 16 weeks pregnant, then you can and should have both vaccines. You can have them together or separately, the vaccines don’t interfere with each other if given together.

Although the vaccine won’t completely guarantee that your baby won’t get whooping cough, it does make it very unlikely.

Getting vaccinated

The best time to get vaccinated to protect your baby is from week 16 of your pregnancy. If you are in week 16 of your pregnancy or beyond, your GP will arrange for you to get this vaccine. If you don’t hear anything, talk to your GP to make sure you don’t miss out.

If you get the vaccine less than two weeks before giving birth, antibodies may not have had time to develop and be passed to your baby in big enough quantities. However, it will still reduce the risk of you infecting the baby.

Your baby will still need to be vaccinated as normal starting at two months old.

If you are in week 16 of your pregnancy or beyond, your GP will arrange for you to get this vaccine. If you haven’t heard from your GP, contact them to arrange an appointment.

Are there alternatives to the vaccine

There is no other way to protect your baby from whooping cough. Recently, some young babies in the UK have died from whooping cough before they were old enough to receive their first vaccine.

Getting vaccinated during pregnancy provides antibodies that will be passed to the baby so he or she has some protection during the first few weeks of life when whooping cough is most serious.

The earliest your baby can receive the vaccine themselves is at two months, as newborn babies do not respond well to the vaccine. Three doses are needed to get full protection.

Breastfeeding alone will not protect your child from whooping cough before their first injection, as not enough immunity is passed in the breast milk to your baby.

Whooping cough (pertussis) rates have risen sharply in recent years and babies who are too young to start their vaccinations are at greatest risk.

Young babies with whooping cough are often very unwell and most will be admitted to hospital because of their illness. When whooping cough is particularly severe, they can die.

Pregnant women can help protect their babies by getting vaccinated – ideally from 16 weeks up to 32 weeks pregnant. If for any reason you miss having the vaccine, you can still have it up until you go into labour.

Why are pregnant women advised to have the vaccine?

Getting vaccinated while you're pregnant is highly effective in protecting your baby from developing whooping cough in the first few weeks of their life.

The immunity you get from the vaccine will pass to your baby through the placenta and provide passive protection for them until they are old enough to be routinely vaccinated against whooping cough at 8 weeks old.

When should I have the whooping cough vaccine?

The best time to get vaccinated to protect your baby is from 16 weeks up to 32 weeks of pregnancy. This maximises the chance that your baby will be protected from birth, through the transfer of your antibodies before he or she is born.

If for any reason you miss having the vaccine, you can still have it up until you go into labour. However, this is not ideal, as your baby is less likely to get protection from you. At this stage of pregnancy, having the vaccination may not directly protect your baby, but would help protect you from whooping cough and from passing it on to your baby.

Is the vaccine safe in pregnancy?

It's understandable that you might have concerns about the safety of having a vaccine during pregnancy, but there's no evidence to suggest that the whooping cough vaccine is unsafe for you or your unborn baby.

Pertussis-containing vaccine (whooping cough vaccine) has been used routinely in pregnant women in the UK since October 2012, and the Medicines and Healthcare products Regulatory Agency (MHRA) is carefully monitoring its safety. The MHRA's study of around 20,000 vaccinated women has found no evidence of risks to pregnancy or babies.

To date, around 69% of eligible pregnant women have received the whooping cough vaccine with no safety concerns being identified in the baby or mother.

A number of other countries, including the US, Argentina, Belgium, Spain, Australia and New Zealand, currently recommend vaccination against whooping cough in pregnancy.

Is whooping cough vaccination in pregnancy working?

Yes, it is. Published research from the UK vaccination programme shows that vaccinating pregnant women against whooping cough has been highly effective in protecting young babies until they can have their first vaccination when they are 8 weeks old.

Babies born to women vaccinated at least a week before birth had a 91% reduced risk of becoming ill with whooping cough in their first weeks of life, compared to babies whose mothers had not been vaccinated.

An additional benefit is that the protection the mother receives from the vaccination will lower her own risk of infection and of passing whooping cough on to her baby.

Which whooping cough vaccine will I be given?

As there is no whooping cough-only vaccine, the vaccine you'll be given also protects against polio, diphtheria and tetanus. The vaccine is called Boostrix IPV.

Boostrix IPV is similar to the 4-in-1 vaccine – the pre-school booster that's routinely given to children before they start school. 

You can read the manufacturer's patient information leaflet for Boostrix IPV (PDF, 91kb).

The manufacturer's leaflet says there's no information on the use of Boostrix IPV in pregnancy. Should it be used in pregnancy? 

The licence for Boostrix IPV allows for its use in pregnancy when clearly needed, and when the possible benefits outweigh the possible risks.

It is standard practice with most medicines not to test them on pregnant women. This is why the manufacturer's information leaflet includes this statement, and not because of any specific safety concerns or evidence of harm in pregnancy.

Whooping cough-containing vaccine has been used routinely in pregnant women in the UK since October 2012, and the Medicines and Healthcare products Regulatory Agency (MHRA) is carefully monitoring its safety. The MHRA's study of around 20,000 women vaccinated with Repevax, the whooping cough vaccine previously offered to pregnant women, found no evidence of risks to pregnancy or pregnancy outcome.

Boostrix (similar to Boostrix IPV, but without the polio component) is one of the vaccines routinely recommended in the US for immunisation of pregnant women. There have been no reported safety concerns in the US with the use of the vaccine in pregnancy.

There is no evidence of risk to the pregnant woman or unborn child with inactivated vaccines like Boostrix IPV. An inactivated vaccine is one that does not contain "live" vaccine.

Read more about why vaccines are safe and important.

What are the side effects of the whooping cough vaccine?

You may have some mild side effects such as swelling, redness or tenderness where the vaccine is injected in your upper arm, just as you would with any vaccine. These only last a few days. Other side effects can include fever, irritation at the injection site, swelling of the vaccinated arm, loss of appetite, irritability and headache. Serious side effects are extremely rare.

What is whooping cough?

Whooping cough (medically known as pertussis) is a serious infection that causes long bouts of coughing and choking, making it hard to breathe. The "whoop" is caused by gasping for breath after each bout of coughing, though babies do not always make this noise.

Read more about whooping cough vaccination in the leaflet Whooping cough and pregnancy (PDF, 183kb) from Public Health England.

What are the rare side effects of whooping cough vaccine?

Possible side effects of whooping cough vaccine may include fever, redness and soreness or swelling where the injection was given, nausea, headache, tiredness and aching muscles. More serious side effects are extremely rare but can include severe allergic reactions.

When do side effects start after whooping cough vaccine?

If you experience soreness, redness, swelling, or an itchy rash at the injection site about a week after getting the booster, you likely have COVID arm. COVID arm is a rare reaction. It typically occurs around one week after the first or second shot vaccination.

Does the whooping cough vaccine affect the baby?

Whooping cough vaccines are safe. In particular, getting the whooping cough vaccine called Tdap during pregnancy is safe for both women and their babies. The whooping cough vaccine called DTaP is safe for children. Getting Tdap during pregnancy does not put women at increased risk for pregnancy complications.

Should I get whooping cough vaccine while pregnant?

All pregnant women should get the Tdap vaccine during each pregnancy. The vaccine helps your body make antibodies to protect you from disease. These antibodies pass to your fetus and can protect your newborn until he or she can get the Tdap vaccine at 2 months old.